Tottenham Hotspur take on Newcastle United at Wembley on Wednesday night, with the London side desperate for three points at Wembley to shore-up a Premier League top-four finish.

Spurs have home clashes against Rafa Benitez’s men and Leicester City to play, with four points enough to ensure Champions League football for next season.

Should Tottenham win both games, Mauricio Pochettino’s men will leapfrog Liverpool and finish third.

Spurs have confirmed their team news on the official website ahead of the clash, with four first-team men unable to feature.

The major issue is in the heart of the Tottenham midfield, with Harry Winks, Mousa Dembele and Eric Dier all unavailable to play.

Pochettino started Victor Wanyama and Christian Eriksen in the boiler room against West Bromwich Albion last time out and may be forced to do the same here.

Winks is out for the remainder of the Tottenham season, Dier is suffering from illness and Dembele has not recovered from an ankle knock.

Kieran Trippier is set to continue at right-back also, with Serge Aurier out of the Newcastle clash with a hamstring strain.

In more-positive news, Pochettino has confirmed that Jan Vertonghen, who limped out of the defeat to West Brom, is fit to play.

“Jan is okay. He’s trained well and he’s fit for tomorrow,” the Tottenham boss said.

“With Eric, it’s normal that he needs a minimum of 48 hours to recover to be available for training. We hope he’ll be available for the weekend.”

It will be interesting to see if Pochettino opts to continue with a three-man central defence, which he fielded against West Brom, or reverts to the back four that the side has mostly been using in 2018.

One way or the other, three points is a necessity here.

Chelsea are playing against Hudderfield Town on Wednesday also and defeat to Newcastle could leave Tottenham in fifth place going into the final day of the season.

It has been a long and hard campaign and the players need a break – but two victories are needed first to ensure all the hard work does not unrewarded.