England have confirmed on Twitter that they will be without injured Tottenham Hotspur duo Harry Kane and Harry Winks for their forthcoming international friendlies against Germany and Brazil.

Both players were substituted during the Lilywhites’ 1-0 win over Crystal Palace on Sunday and join team-mate Dele Alli on the Three Lions’ absentee list.

Former Spurs man Jake Livermore has been called up to the squad as a replacement.

The injuries to Kane and Winks will come as a blow to national team manager Gareth Southgate as he begins his preparations for next summer’s World Cup.

The pair were on song in the most recent round of international fixtures as England secured their place in Russia for the finals.

Kane has emerged as a potential long-term captain following the retirement of Wayne Rooney and bagged winning goals against Slovenia and Lithuania in October.

Meanwhile Winks made his debut in the second of those games, turning in a man-of-the-match performance and staking a strong claim to be a more permanent member of the senior setup.

The youngster was clearly upset at having to withdraw from the squad and took to Twitter to express his frustration at missing matches against such prestigious opposition.

Southgate’s men face Germany at Wembley on Friday before hosting Brazil on November 14.